Doyle A Siever, Ph.D.

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With over two decades of scientific, legal, and intellectual property expertise as a research scientist and attorney (in-house corporate counsel and IP law firm associate), Doyle Siever brings a wealth of intellectual property law and biological research experience in biomedical, biopharmaceutical and biotech sectors. Dr. Siever is highly skilled in providing a variety of intellectual property services to domestic and international clients having patent application and trademark portfolios ranging from small and germinating to large, maturing and complex.  Services include: providing patentability and freedom-to-operate opinions; non-infringement and validity opinions; patent prosecution, procurement & defenses; trademark searches, application filings, prosecution & defenses; business and financial due diligence investigations; and, strategic advice in each of these areas.

Dr. Siever’s biomedical experience includes 11 years of laboratory research involving molecular biology, virology, cell & cancer biology, immunology, and cell signal transduction research performed under NIH sponsorships at The Pennsylvania State University College of Medicine (Ph.D; Microbiology and Immunology) and Duke University (post-doctoral research). In addition to earning his J.D. from Georgetown University, Dr. Siever’s legal background further includes serving as in-house counsel at Human Genome Sciences, Inc. and Precigen Inc. (most recently as Vice President Intellectual Property Counsel) and as Associate Attorney at a prominent intellectual property law firm based in Washington, D.C.

Intellectual property (IP) subject matter expertise and experience include protection of IP around antibodies & other immunologic effectors, immunotherapeutics (e.g, genetically modified immune cells, chimeric antigen receptors, molecular vaccine technology), gene expression and nucleic acid delivery technology, nucleic acid and protein engineering, viral and non-viral vector engineering, genetically modified organisms (e.g., plant-based agricultural products, vertebrate & invertebrate organisms), biomedical devices, trademarks and trade secret practice.

Dr. Siever is admitted to practice law in Maryland and is registered to practice before the United States Patent and Trademark Office (registration no. 47,088). He earned his J.D. from Georgetown University Law Center and his Ph.D. from the Pennsylvania State University College of Medicine.

  • Maryland
  • U.S. Patent and Trademark Office
  • J.D., Georgetown University Law Center
  • Ph.D. in Microbiology & Immunology , Pennsylvania State University College of Medicine, 1996
  • B.S. in Biology and Chemistry (Dual Major), Magna cum laude, Messiah University, , 1988

  • Siever, D.A. and Erickson, H.P., “Extracellular Annexin II,” International Journal of Biochemistry and Cell Biology, 29:1219-23 (1997).

  • Monschau, B., Kremoser, C., Ohta, K., Tanaka, H., Kaneko, T., Yamada, T., Handwerker, C., Hornberger, M.R., Loschinger, J., Pasquale, E.B., Siever, D.A., Verderame, M.F., Muller, B., Bonhoeffer, F., Drescher, U., “Shared and Distinct Functions of RAGS and ELF-1 in Guiding Retinal Axons,”  EMBO Journal, 16:1258-1267 (1997).

  • Siever, D.A., “Identification and characterization of the CEK7 receptor tyrosine kinase,” Dissertation, Pennsylvania State University (1996).

  • Shao, H., Lou, L., Pandey, A., Verderame, M.F., Siever, D.A., and Dixit, V.M., “cDNA Cloning and Characterization of a Cek7 Receptor Protein Tyrosine Kinase Ligand that is Identical to the Ligand (ELF-1) of the Mek-4 and Sek Receptor Protein Tyrosine Kinases,” Journal of Biological Chemistry, 270:3467-3470 (1995).

  • Siever, D.A. and Verderame, M.F., “Identification and Complete Cek7 Receptor Protein

    Tyrosine Kinase Coding Sequence and cDNAs of Alternatively Splice Transcripts,”  Gene, 148:219-226 (1994).

  • Verderame, M.F. and Siever, D.A., “Isolation of a Chicken cDNA Encoding a Novel Receptor Protein Tyrosine Kinase,” 22nd Annual Keystone Symposia on Molecular and Cellular Biology, Journal of Cellular and Biochemistry, Supplement 17A, p. 243 (1993).

 

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